Toxicokinetics of Bisphenol A Scientific Opinion of the Panel on Food additives, Flavourings, Processing aids and Materials in Contact with Food (AFC)
نویسندگان
چکیده
The Panel has been asked to reconsider the possible age-dependent toxicokinetics of BPA in animals and humans and their implication for hazard and risk assessment of BPA in food. The Panel concluded that the exposure of a human fetus to free BPA would be negligible due to the maternal capacity for conjugation whereas the fetal rat would be exposed to free BPA from the maternal circulation. Taking account of data in human neonates on compounds structurally related to BPA which undergo glucuronidation/sulphation, the Panel considers that there is sufficient capacity in the neonate to conjugate BPA at doses below 1 mg/kg bw (the Panel noted that exposures at the TDI of 0.05 mg/kg bw are 20 fold lower than this).
منابع مشابه
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تاریخ انتشار 2008